Mixed effects model fit for annual rates of clinical decline, allowing for linear change with age.

<p>Data points plotted, with 95% confidence intervals, are independent estimates of rates of change for successive 5-year intervals for a mixed effects model fit without an age-dependent term. Slopes and p-values of the linear fits for each diagnostic group are shown in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0042325#pone-0042325-t003" target="_blank">Table 3</a>. Legend: red = AD; blue = MCI; green = HC.