Loss of CD166 does not block WT prostate development and stem/progenitor cell function.
- Jing Jiao (121723)
- Antreas Hindoyan (146395)
- Shunyou Wang (146403)
- Linh M. Tran (146410)
- Andrew S. Goldstein (146415)
- Devon Lawson (146421)
- Donghui Chen (146426)
- Yunfeng Li (37710)
- Changyong Guo (146431)
- Baohui Zhang (146437)
- Ladan Fazli (146441)
- Martin Gleave (146446)
- Owen N. Witte (146451)
- Isla P. Garraway (146456)
- Hong Wu (105254)
Publication date
August 2012
DOIAbstract
<p>(A) Top: The gross anatomy of the prostate of <i>WT</i> and <i>CD166−/−</i> mice at 8 weeks of age, scale bar: 2 mm. Bottom: HE staining of DLP section from WT and <i>CD166</i><sup>−/−</sup> mice at 8 weeks of age, scale bar: 200 µm. (B) Comparison of sphere formation from total unsorted prostate cells (5000 per 12-well) between <i>CD166<sup>+/−</sup></i> and <i>CD166<sup>−/−</sup></i> prostates. Data represented as mean +/− STD (p>0.05, n = 3). (C) Comparison of LSC<sup>hi</sup> content between <i>CD166<sup>+/−</sup></i> and <i>CD166<sup>−/−</sup></i> prostates at 8–12 weeks age (p>0.05, n = 5).</p
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