Inhibition of WT-SMC growth but promotion of CSE-KO-SMC growth by estrogen.

<p>WT-SMCs and CSE-KO-SMCs were treated with estrogen at the indicated concentrations for 72 h, and then cell viability and cell proliferation were measured. Cell viability of WT-SMCs (<b><i>A</i></b>) and CSE-KO-SMCs (<b><i>B</i></b>) were measured by MTT assay and cell proliferation of WT-SMCs (<b><i>C</i></b>) and CSE-KO-SMCs (<b><i>D</i></b>) were analyzed by BrdU incorporation assay. The control cells without estrogen treatment were considered as 100% viable. Data were from five independent experiments. * p<0.05 <i>vs</i>. control group.