Effects of IL-10 deficiency on systemic and local proinflammatory cytokine and chemokine production after acute MCMV infection.

<p>(A, C, E) Serum samples and (B, D, F) liver leukocyte conditioned media were prepared from uninfected or MCMV-infected C57BL/6J (WT) or IL-10^−/− mice and tested for (A and B) IFN-γ, (C and D) TNF-α, and (E and F) CXCL9 by standard sandwich ELISA. <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0042850#s2" target="_blank">Results</a> are the combined data of two to four independent experiments and show the means ± SE (n = 5–18 mice per group for each time point tested). Asterisks denote statistically significant differences between WT and IL-10^−/− groups, where p values are ≤0.05 (Student's T test).