Drug response network analysis based on the change in protein expression over time.

<p>Spheres represent proteins and lines connecting spheres indicate interactions between proteins. Large spheres are proteins differentially expressed in response to FLC; red indicates proteins induced or up-regulated; green indicates proteins suppressed or down-regulated; and blue indicates no data at that time point. Smaller spheres are colour-mapped according to Gene Ontology biological process. The network analysis reveals correlated processes in response to FLC treatment from 3 h to 6 h time points. See <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0042835#pone-0042835-g005" target="_blank">Figure 5</a> for the Gene Ontology terms of these proteins. [GEOMI Force Directed Layout: spring = 50, origin = 80, repulsion = 12, planar = 100].