The mouse skin 682-gene signature is significantly present in mouse mammary and lung carcinoma models showing p53 inhibition.

<p>Heatmaps of the 682-gene signature transcripts from (<b>A</b>) primary breast carcinomas and normal mammary glands from different transgenic GEMMs (upper panel), and from (<b>B</b>) primary and metastatic lung adenocarcinomas and normal lungs from different transgenic GEMMs (upper panel) (<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0042494#pone.0042494.s011" target="_blank">Table S1</a>) are shown. The T-values returned by Student’s t-test comparisons between normal skin and carcinoma samples in which the 682-gene signature was determined (GSE11990) were used to build a centroid template. The Pearson correlation coefficient (and the corresponding p-value) with respect to the centroid was calculated for each mouse sample. Samples were ordered from left to right based on increasing correlation. Probesets are ordered from top to bottom based on T-values (see <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0042494#s4" target="_blank">Materials and Methods</a>). Samples within blue rectangles are normal skin samples and skin tumour samples. The number of samples in each group is shown under the heatmaps. Pearson values are shown in the middle panel. Values range from −1 (negative correlation, bluish background) to +1 (positive correlation, reddish background). The significance value for the correlation is shown in the lower panel as –log₁₀(p-val). The red line indicates p-val = 0.01. Genotypes highlighted in red are models with p53 alterations significantly correlated with the 682-signature. Samples highlighted in pink are metastases. In (<b>B</b>), the Kras (1) and Kras/Lkb1^L/L (1) samples are from the GSE6135 dataset; the Kras (2) and Kras/Lkb1^L/L (2) samples are from the GSE21581 dataset.