Binding motif of taxol in WT and mutated tubulins.

<p>The drug-receptor complexes were obtained by simulating the lowest energy docked complexes for 10 ns in explicit water. Taxol is shown in licorice and the tubulin residues involved in interactions are colored according to atom type – green: C, red: O, blue: N, white: H. Results shown for - a) WT b) T274I c) R282Q d) Q292E. Mutations resulted in altered mode of drug binding and loss of characteristic drug-receptor contacts.