LAT expression correlates with HSV-1 genome pattern.

<p>(A) TG sections obtained from SC16/lip-infected mice at 28 d.p.i. were processed for RNA-FISH using a 2-kb LAT RNA-FISH probe and an HSV-1 DNA-FISH probe as in <a href="http://www.plospathogens.org/article/info:doi/10.1371/journal.ppat.1002852#ppat-1002852-g001" target="_blank">Figure 1D</a>. The dotted lines outline the nucleus. Each labeling is shown as separated channels on the right panel. Wide-field imaging. Scale bar = 5 µm. (B) TG sections obtained from three mice at 28 d.p.i. were processed as in (A). The 2-kb LAT RNA-FISH signal and DNA-FISH pattern were quantified and plotted as the fraction of LAT+ neurons among neurons with the various patterns. (C) Same data set as in (B), plotted as the fraction of each pattern in LAT+ neurons. Bars show the standard error of the mean.