Schematic representation of the pathways involved in cardiac hypertrophy in ErbB2 transgenic mice.

<p>ErbB2 over-expression results in increased levels of other ErbB family members, EGFR, ErbB3 and ErbB4. ErbB family signals to downstream PI3K, AKT and p70/85S6K proteins, which leads to activation of translational machinery and hypertrophic phenotype.