Rapamycin reduces elevated VEGF and HIF-1 levels in hemangioma endothelial cells.

<p><b>A:</b> Immunoblotting showing the effects of rapamycin on p70S6K phosphorylation, HIF-1α expression and VEGF-A₁₆₅ expression in normal (HDMEC) or hemangioma (EC2, EC17B, EC21A) endothelial cell lysates. <b>B and C:</b> Luminex analysis showing reduced expression of HIF-1α (B) and VEGF-A₁₆₅ (C) in hemangioma endothelial cells treated with rapamycin. Data represent mean (n = 3)±SD; *<i>P</i><0.05 compared to vehicle.