TAp73α activated the JNK pathway.

<p>(A) Increase of p-JNK and p-c-Jun was detected in TAp73α–overexpressed cells (SKOV3 C8, C24 and C28 and OVCA433 C1, C7 and C12) and further enhanced upon cisplatin treatment (4 μg/ml for 24 h), when compared to the controls (P: parental cells; V: empty vector control). (B) TAp73α-overexpressed cells (SKOV3 C8 and OVCA433 C1) were exposed to 4 μg/ml cisplatin for different periods of time, or to different doses of cisplatin for 12 h. The p-JNK level was measured by western blot analysis. (C) DNp73α (GFP-DNp73α) was over-expressed in SKOV3 (D2) and OVCA433 (D18) cells. (D) No JNK activation was observed in DNp73α-overexpressed cells (SKOV3 D2 and OVCA433 D18).