TRPA1 mediates IL-8 release by acrolein from human airway/lung cells in primary culture.

<p>Overnight exposure to acrolein (ACR) induces IL-8 release from small airway epithelial cells (SAEC) (<b>A</b>), normal human lung fibroblasts (NHLF) (<b>B</b>) and human bronchial smooth muscle cells (HBSMC) (<b>C</b>) in a concentration–dependent manner. IL-8 release evoked by ACR is reduced by HC-030031 (HC, 30 µM) and AP18 (10 µM). Each column represents mean ± SEM of at least 3 independent experiments. ^§<i>P</i><0.05 vs. Basal group or Veh/Veh-ACR; ^*<i>P</i><0.05 vs. Veh/ACR.