Decreased cytokine and co-stimulatory molecule expression in AEP<sup>−/−</sup> DCs <i>in vivo</i> upon TLR7 ligand sensing.
- Sophia Maschalidi (142514)
- Signe Hässler (142518)
- Fany Blanc (142521)
- Fernando E. Sepulveda (142523)
- Mira Tohme (142525)
- Michel Chignard (17499)
- Peter van Endert (49012)
- Mustapha Si-Tahar (17500)
- Delphyne Descamps (142528)
- Bénédicte Manoury (142531)
Publication date
August 2012
DOIAbstract
<p>(A) FACS analysis of <i>in vivo</i> maturation of spleen CD11c<sup>+</sup> cells 4 h after i.v. injection of 10 µg of imiquimod (left panel) or 1 µg of LPS (right panel) compared to no TLR ligand stimulation equivalent to 1. (B) IL-6 (left panel) and IL-12p40 (right panel) secretion were measured in serum of AEP<sup>+/+</sup> or AEP<sup>−/−</sup> mice 2 h after i.v. injection with imiquimod or PBS. (n = 9 animals for imiquimod; n = 2 animals for PBS; mean ± SEM for A and B, ** p<0.01, *** p<0.001).</p
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