Genomic structure of the IRCS mice in the region of interest of chromosome 1.

<p>The map presents the genomic background, spretus or musculus, of the 7 recombinant substrains (Rc) in the chromosomal region corresponding to <i>Led2</i> QTL. Recombinant strains were generated at the Pasteur institute (Paris) from 66HMMU1 strain by recombination events inside the MMU1 <i>spretus</i> segment. These strains have been genotyped using 24 polymorph markers. Marker positions are given in megabase pairs (Mb). “S" corresponds to the marker in a spretus homozygous form and “B" to the marker in a musculus (B6) homozygous form. The two minimal <i>spretus</i> regions (<i>Led2minA</i> with main effect and <i>Led2minB</i> with probable weak effect) responsible for the phenotype of interest are highlighted in gray and in gray hatched when coexisting in the same substrain.