Formation of highly aggressive endometrial adenocarcinoma in <i>Lkb1^cko;Pten^cko</i> mice.

<p>(A and B) Female reproductive tracts from <i>Lkb1^fl/fl;Pten^fl/fl</i> and <i>Lkb1^cko;Pten^cko</i> mice. Arrowheads point to overgrowths. Arrows: Cervix and vagina. (C) <i>Lkb1^cko;Pten^cko</i> mice with abnormal growths (arrowheads) projecting through their vaginas. (D and E) Uterine (Ut) and cervical/vaginal tumors (arrow) in double mutant mice. H&E sections of 5 week and 9 week old control (F, H, L)) and mutant (G, I, M) uteri. Colocalization of CK8 (green) and αSMA (red) in control (J, N and O) and double mutant (K, P and Q) uteri. Ut: uterus. Bars: 50 um.