<p>The mean MCCs of the mRNA, microRNA and methylation gene sets were 0.897, 0.702 and 0.561, respectively. The MCCs of the mRNA sets were significantly greater than the MCCs of the microRNA sets with a one-sided t-test p-value of less than 2.2e-16, and the MCCs of the microRNA sets were, in turn, significantly greater than the MCCs of the methylation sets with a one-sided t-test p-value of less than 2.2e-16.</p
<p>(a). Gene expression was inverse to the density of adjacent probes enriched for 5 mC (data from 1...
<p>CpG islands and shores across the genome were categorized into those located upstream from a tran...
<p>Gene expression level is measured by fluorescence in single colour arrays for genes that are natu...
<p>First, for each Gene Ontology (GO) term, we defined three gene sets: the methylation set, the mic...
<p>(<b>A</b>) MiRNAs with ≥ 10 target genes are involved with more true MDAs than those targeting le...
<p>(A) Tag density profile of H3K27me3 distribution across different gene groups from <a href="http:...
<p>The genes were divided into five bins according to their methylation levels, and then the average...
<p><sup>a</sup>number of differentially methylated probes within gene</p><p><sup>b</sup>methylated (...
<p>Box plots illustrating the DNA methylation of the miRNA genes investigated. The names of the miRN...
Integrating high-throughput data obtained from different molecular levels is essential for understan...
<p>Genes are ordered by Mann-Whitney <i>p-value (</i>** p-value<0.0001 and * p-value<0.05). Methylat...
<p>(A) Loss of MMSET expression in t(4;14)+ cells depletes H3K36 methylation and increases H3K27 met...
<p>A. Representative view of genes that gain ectopic H3K9m2 and non-CG methylation. Left panel: IGB ...
Integrating high-throughput data obtained from different molecular levels is essential for understan...
<p>(A–F) For a single AML patient we categorized the gene methylation into 4 groups (>0.4, 0.4–0.6, ...
<p>(a). Gene expression was inverse to the density of adjacent probes enriched for 5 mC (data from 1...
<p>CpG islands and shores across the genome were categorized into those located upstream from a tran...
<p>Gene expression level is measured by fluorescence in single colour arrays for genes that are natu...
<p>First, for each Gene Ontology (GO) term, we defined three gene sets: the methylation set, the mic...
<p>(<b>A</b>) MiRNAs with ≥ 10 target genes are involved with more true MDAs than those targeting le...
<p>(A) Tag density profile of H3K27me3 distribution across different gene groups from <a href="http:...
<p>The genes were divided into five bins according to their methylation levels, and then the average...
<p><sup>a</sup>number of differentially methylated probes within gene</p><p><sup>b</sup>methylated (...
<p>Box plots illustrating the DNA methylation of the miRNA genes investigated. The names of the miRN...
Integrating high-throughput data obtained from different molecular levels is essential for understan...
<p>Genes are ordered by Mann-Whitney <i>p-value (</i>** p-value<0.0001 and * p-value<0.05). Methylat...
<p>(A) Loss of MMSET expression in t(4;14)+ cells depletes H3K36 methylation and increases H3K27 met...
<p>A. Representative view of genes that gain ectopic H3K9m2 and non-CG methylation. Left panel: IGB ...
Integrating high-throughput data obtained from different molecular levels is essential for understan...
<p>(A–F) For a single AML patient we categorized the gene methylation into 4 groups (>0.4, 0.4–0.6, ...
<p>(a). Gene expression was inverse to the density of adjacent probes enriched for 5 mC (data from 1...
<p>CpG islands and shores across the genome were categorized into those located upstream from a tran...
<p>Gene expression level is measured by fluorescence in single colour arrays for genes that are natu...