Effects of riociguat and sildenafil on apoptosis and cell proliferation in the lung tissue of SUHx rats.

The effect of CK-165 and sildenafil in rats with monocrotaline-induced pulmonary hypertension.

David Ho (324313)
Li Chen (5749)
Xin Zhao (71840)
Nicquanna Durham (324318)
Malar Pannirselvam (324321)
Dorothy E. Vatner (324324)
David J. Morgans (324326)
Fady I. Malik (324328)
Stephen F. Vatner (212999)
You-Tang Shen (324329)

February 2013

CK-165 decreased RSVP following intratracheal nebulization of 30 mg/kg in rats with monocrotaline...

Riociguat for treatment of experimental right heart hypertrophy

Schermuly, Ralph Theo

October 2012

RationaleRight heart failure is a prevalent mechanism of cardiovascular collapse and distinctly diff...

Antiproliferative effect of sildenafil on human pulmonary artery smooth muscle cells

TANTINI, BENEDETTA
MANES, ALESSANDRA
FIUMANA, EMANUELA
PIGNATTI, CARLA
GUARNIERI, CARLO
ZANNOLI, ROMANO
BRANZI, ANGELO
GALIE', NAZZARENO

January 2005

Pulmonary arterial hypertension (PAH) is characterized by vasoconstriction and by obstructive change...

Effects of riociguat and sildenafil on sGC and eNOS protein levels, and cGMP concentration in the lung tissue of SUHx rats.

Michaela Lang (117542)
Baktybek Kojonazarov (142859)
Xia Tian (142861)
Anuar Kalymbetov (142863)
Norbert Weissmann (5495)
Friedrich Grimminger (142867)
Axel Kretschmer (142870)
Johannes-Peter Stasch (142873)
Werner Seeger (5494)
Hossein Ardeschir Ghofrani (142879)
Ralph Theo Schermuly (142882)

August 2012

(A) Western blotting of eNOS, sGCα1 and sGCβ1, (B) densitometric analysis of sGCα1/β-actin, (C) d...

Effects of riociguat and sildenafil on pulmonary vascular remodeling in SUHx rats.

Michaela Lang (117542)
Baktybek Kojonazarov (142859)
Xia Tian (142861)
Anuar Kalymbetov (142863)
Norbert Weissmann (5495)
Friedrich Grimminger (142867)
Axel Kretschmer (142870)
Johannes-Peter Stasch (142873)
Werner Seeger (5494)
Hossein Ardeschir Ghofrani (142879)
Ralph Theo Schermuly (142882)

August 2012

(A) Proportion of non-, partially or fully muscularized pulmonary arteries as a percentage of the...

Riociguat increases lung tissue cGMP levels.

Keyur Donda (5497400)
Ronald Zambrano (5497406)
Younghye Moon (200726)
Justin Percival (5497412)
Ruben Vaidya (5497418)
Fredrick Dapaah-Siakwan (5497409)
Shihua Luo (5497415)
Matthew R. Duncan (5497421)
Yong Bao (296790)
Luqing Wang (5257895)
Ling Qin (68169)
Merline Benny (5497403)
Karen Young (833929)
Shu Wu (492135)

July 2018

Riociguat significantly increased cGMP concentration in hyperoxia-exposed rats as compared with p...

Effects of riociguat and sildenafil on RVH and fibrosis in SUHx rats.

Michaela Lang (117542)
Baktybek Kojonazarov (142859)
Xia Tian (142861)
Anuar Kalymbetov (142863)
Norbert Weissmann (5495)
Friedrich Grimminger (142867)
Axel Kretschmer (142870)
Johannes-Peter Stasch (142873)
Werner Seeger (5494)
Hossein Ardeschir Ghofrani (142879)
Ralph Theo Schermuly (142882)

August 2012

(A) Ratio of the RV to LV+S and (B) RV collagen contents of different treatment groups. *p...

Effects of sildenafil treatment on cytokine expressions.

Tamas Kiss (2012410)
Krisztina Kovacs (1286178)
Andras Komocsi (617401)
Adrienn Tornyos (617402)
Petra Zalan (617403)
Balazs Sumegi (81498)
Ferenc Gallyas Jr (492218)

August 2014

Nitrocellulose based rat cytokine array assay was performed on lung homogenates of untreated (Sha...

Effects of riociguat on mRNA expression of osteopontin (OPN), plasminogen activator inhibitor-1 (PAI-1) and tissue inhibitor of matrix metalloproteinase-1 (TIMP-1) in the left ventricle and the renal cortex in the vehicle (n = 7) - and riociguat-treated (3 or 10 mg/kg/d, n = 11 per group) Dahl/ss rats maintained on a high-salt diet.

Sandra Geschka (347996)
Axel Kretschmer (142870)
Yuliya Sharkovska (311913)
Oleg V. Evgenov (347997)
Bettina Lawrenz (347999)
Andreas Hucke (348000)
Berthold Hocher (311916)
Johannes-Peter Stasch (142873)

February 2013

Healthy, age-matched animals were used as controls (n = 10). Data are mean±SEM; *p<0.05 vs. the v...

The Soluble Guanylate Cyclase Stimulator Riociguat Ameliorates Pulmonary Hypertension Induced by Hypoxia and SU5416 in Rats

Lang Michaela
Kojonazarov Baktybek
Tian Xia
Kalymbetov Anuar
Weissmann Norbert
Grimminger Friedrich
Kretschmer Axel
Stasch Johannes-Peter
Seeger Werner
Ghofrani Hossein Ardeschir
Schermuly Ralph Theo

August 2012

The nitric oxide (NO)–soluble guanylate cyclase (sGC)–cyclic guanosine monophosphate (cGMP) signal-t...

Sildenafil potentiates the antitumor activity of cisplatin by induction of apoptosis and inhibition of proliferation and angiogenesis

El-Naa MM
Othman M
Younes S

November 2016

Mona Mohamed El-Naa,1 Mohamed Othman,2,3 Sheren Younes4,5 1Faculty of Pharmacy, October University f...

Soluble Guanylate Cyclase Stimulation Prevents Fibrotic Tissue Remodeling and Improves Survival in Salt-Sensitive Dahl Rats

Geschka Sandra
Kretschmer Axel
Sharkovska Yuliya
Evgenov Oleg V.
Lawrenz Bettina
Hucke Andreas
Hocher Berthold
Stasch Johannes-Peter

July 2011

A direct pharmacological stimulation of soluble guanylate cyclase (sGC) is an emerging therapeutic a...

Soluble guanylate cyclase stimulation prevents fibrotic tissue remodeling and improves survival in salt-sensitive Dahl rats.

Sandra Geschka
Axel Kretschmer
Yuliya Sharkovska
Oleg V Evgenov
Bettina Lawrenz
Andreas Hucke
Berthold Hocher
Johannes-Peter Stasch

A direct pharmacological stimulation of soluble guanylate cyclase (sGC) is an emerging therapeutic a...

Effects of sildenafil on skeletal and cardiac muscle atrophy.

Barbara Rinaldi (439067)
Maria Donniacuo (439068)
Loredana Sodano (439069)
Giulia Gritti (439070)
Simona Signoriello (362962)
Elisabetta Parretta (439071)
Liberato Berrino (439072)
Konrad Urbanek (439073)
Annalisa Capuano (439074)
Francesco Rossi (324859)

July 2013

PGC-1α, FoxO3a, Atrogin-1 and MuRF-1 gene expression was measured by real-time PCR. Left panel (A...

Sildenafil attenuates hypoxic pulmonary remodelling by inhibiting bone marrow progenitor cells.

Shirley Favre (7788320)
Elisa Gambini (213649)
Patrizia Nigro (6080966)
Alessandro Scopece (7788323)
Paola Bianciardi (338718)
Anna Caretti (7178273)
Giulio Pompilio (103510)
Antonio F. Corno (7731857)
Giuseppe Vassalli (338722)
Ludwig K. von Segesser (7788326)
Michele Samaja (338725)
Giuseppina Milano (103519)

November 2016

The recruitment of bone marrow (BM)-derived progenitor cells to the lung is related to pulmonary rem...

The effect of CK-165 and sildenafil in rats with monocrotaline-induced pulmonary hypertension.

David Ho (324313)
Li Chen (5749)
Xin Zhao (71840)
Nicquanna Durham (324318)
Malar Pannirselvam (324321)
Dorothy E. Vatner (324324)
David J. Morgans (324326)
Fady I. Malik (324328)
Stephen F. Vatner (212999)
You-Tang Shen (324329)

February 2013

CK-165 decreased RSVP following intratracheal nebulization of 30 mg/kg in rats with monocrotaline...

Riociguat for treatment of experimental right heart hypertrophy

Schermuly, Ralph Theo

October 2012

RationaleRight heart failure is a prevalent mechanism of cardiovascular collapse and distinctly diff...

Antiproliferative effect of sildenafil on human pulmonary artery smooth muscle cells

TANTINI, BENEDETTA
MANES, ALESSANDRA
FIUMANA, EMANUELA
PIGNATTI, CARLA
GUARNIERI, CARLO
ZANNOLI, ROMANO
BRANZI, ANGELO
GALIE', NAZZARENO

January 2005

Pulmonary arterial hypertension (PAH) is characterized by vasoconstriction and by obstructive change...

Effects of riociguat and sildenafil on sGC and eNOS protein levels, and cGMP concentration in the lung tissue of SUHx rats.

Michaela Lang (117542)
Baktybek Kojonazarov (142859)
Xia Tian (142861)
Anuar Kalymbetov (142863)
Norbert Weissmann (5495)
Friedrich Grimminger (142867)
Axel Kretschmer (142870)
Johannes-Peter Stasch (142873)
Werner Seeger (5494)
Hossein Ardeschir Ghofrani (142879)
Ralph Theo Schermuly (142882)

August 2012

(A) Western blotting of eNOS, sGCα1 and sGCβ1, (B) densitometric analysis of sGCα1/β-actin, (C) d...

Effects of riociguat and sildenafil on pulmonary vascular remodeling in SUHx rats.

Michaela Lang (117542)
Baktybek Kojonazarov (142859)
Xia Tian (142861)
Anuar Kalymbetov (142863)
Norbert Weissmann (5495)
Friedrich Grimminger (142867)
Axel Kretschmer (142870)
Johannes-Peter Stasch (142873)
Werner Seeger (5494)
Hossein Ardeschir Ghofrani (142879)
Ralph Theo Schermuly (142882)

August 2012

(A) Proportion of non-, partially or fully muscularized pulmonary arteries as a percentage of the...

Riociguat increases lung tissue cGMP levels.

Keyur Donda (5497400)
Ronald Zambrano (5497406)
Younghye Moon (200726)
Justin Percival (5497412)
Ruben Vaidya (5497418)
Fredrick Dapaah-Siakwan (5497409)
Shihua Luo (5497415)
Matthew R. Duncan (5497421)
Yong Bao (296790)
Luqing Wang (5257895)
Ling Qin (68169)
Merline Benny (5497403)
Karen Young (833929)
Shu Wu (492135)

July 2018

Riociguat significantly increased cGMP concentration in hyperoxia-exposed rats as compared with p...

Effects of riociguat and sildenafil on RVH and fibrosis in SUHx rats.

Michaela Lang (117542)
Baktybek Kojonazarov (142859)
Xia Tian (142861)
Anuar Kalymbetov (142863)
Norbert Weissmann (5495)
Friedrich Grimminger (142867)
Axel Kretschmer (142870)
Johannes-Peter Stasch (142873)
Werner Seeger (5494)
Hossein Ardeschir Ghofrani (142879)
Ralph Theo Schermuly (142882)

August 2012

(A) Ratio of the RV to LV+S and (B) RV collagen contents of different treatment groups. *p...

Effects of sildenafil treatment on cytokine expressions.

Tamas Kiss (2012410)
Krisztina Kovacs (1286178)
Andras Komocsi (617401)
Adrienn Tornyos (617402)
Petra Zalan (617403)
Balazs Sumegi (81498)
Ferenc Gallyas Jr (492218)

August 2014

Nitrocellulose based rat cytokine array assay was performed on lung homogenates of untreated (Sha...

Effects of riociguat on mRNA expression of osteopontin (OPN), plasminogen activator inhibitor-1 (PAI-1) and tissue inhibitor of matrix metalloproteinase-1 (TIMP-1) in the left ventricle and the renal cortex in the vehicle (n = 7) - and riociguat-treated (3 or 10 mg/kg/d, n = 11 per group) Dahl/ss rats maintained on a high-salt diet.

Sandra Geschka (347996)
Axel Kretschmer (142870)
Yuliya Sharkovska (311913)
Oleg V. Evgenov (347997)
Bettina Lawrenz (347999)
Andreas Hucke (348000)
Berthold Hocher (311916)
Johannes-Peter Stasch (142873)

February 2013

Healthy, age-matched animals were used as controls (n = 10). Data are mean±SEM; *p<0.05 vs. the v...

The Soluble Guanylate Cyclase Stimulator Riociguat Ameliorates Pulmonary Hypertension Induced by Hypoxia and SU5416 in Rats

Lang Michaela
Kojonazarov Baktybek
Tian Xia
Kalymbetov Anuar
Weissmann Norbert
Grimminger Friedrich
Kretschmer Axel
Stasch Johannes-Peter
Seeger Werner
Ghofrani Hossein Ardeschir
Schermuly Ralph Theo

August 2012

The nitric oxide (NO)–soluble guanylate cyclase (sGC)–cyclic guanosine monophosphate (cGMP) signal-t...

Sildenafil potentiates the antitumor activity of cisplatin by induction of apoptosis and inhibition of proliferation and angiogenesis

El-Naa MM
Othman M
Younes S

November 2016

Mona Mohamed El-Naa,1 Mohamed Othman,2,3 Sheren Younes4,5 1Faculty of Pharmacy, October University f...

Soluble Guanylate Cyclase Stimulation Prevents Fibrotic Tissue Remodeling and Improves Survival in Salt-Sensitive Dahl Rats

Geschka Sandra
Kretschmer Axel
Sharkovska Yuliya
Evgenov Oleg V.
Lawrenz Bettina
Hucke Andreas
Hocher Berthold
Stasch Johannes-Peter

July 2011

A direct pharmacological stimulation of soluble guanylate cyclase (sGC) is an emerging therapeutic a...

Soluble guanylate cyclase stimulation prevents fibrotic tissue remodeling and improves survival in salt-sensitive Dahl rats.

Sandra Geschka
Axel Kretschmer
Yuliya Sharkovska
Oleg V Evgenov
Bettina Lawrenz
Andreas Hucke
Berthold Hocher
Johannes-Peter Stasch

A direct pharmacological stimulation of soluble guanylate cyclase (sGC) is an emerging therapeutic a...

Effects of sildenafil on skeletal and cardiac muscle atrophy.

Barbara Rinaldi (439067)
Maria Donniacuo (439068)
Loredana Sodano (439069)
Giulia Gritti (439070)
Simona Signoriello (362962)
Elisabetta Parretta (439071)
Liberato Berrino (439072)
Konrad Urbanek (439073)
Annalisa Capuano (439074)
Francesco Rossi (324859)

July 2013

PGC-1α, FoxO3a, Atrogin-1 and MuRF-1 gene expression was measured by real-time PCR. Left panel (A...

Sildenafil attenuates hypoxic pulmonary remodelling by inhibiting bone marrow progenitor cells.

Shirley Favre (7788320)
Elisa Gambini (213649)
Patrizia Nigro (6080966)
Alessandro Scopece (7788323)
Paola Bianciardi (338718)
Anna Caretti (7178273)
Giulio Pompilio (103510)
Antonio F. Corno (7731857)
Giuseppe Vassalli (338722)
Ludwig K. von Segesser (7788326)
Michele Samaja (338725)
Giuseppina Milano (103519)

November 2016

The recruitment of bone marrow (BM)-derived progenitor cells to the lung is related to pulmonary rem...

The effect of CK-165 and sildenafil in rats with monocrotaline-induced pulmonary hypertension.

David Ho (324313)
Li Chen (5749)
Xin Zhao (71840)
Nicquanna Durham (324318)
Malar Pannirselvam (324321)
Dorothy E. Vatner (324324)
David J. Morgans (324326)
Fady I. Malik (324328)
Stephen F. Vatner (212999)
You-Tang Shen (324329)

February 2013

CK-165 decreased RSVP following intratracheal nebulization of 30 mg/kg in rats with monocrotaline...

Riociguat for treatment of experimental right heart hypertrophy

Schermuly, Ralph Theo

October 2012

RationaleRight heart failure is a prevalent mechanism of cardiovascular collapse and distinctly diff...

Antiproliferative effect of sildenafil on human pulmonary artery smooth muscle cells

TANTINI, BENEDETTA
MANES, ALESSANDRA
FIUMANA, EMANUELA
PIGNATTI, CARLA
GUARNIERI, CARLO
ZANNOLI, ROMANO
BRANZI, ANGELO
GALIE', NAZZARENO

January 2005

Pulmonary arterial hypertension (PAH) is characterized by vasoconstriction and by obstructive change...

Effects of riociguat and sildenafil on apoptosis and cell proliferation in the lung tissue of SUHx rats.

Abstract

Extracted data

Effects of riociguat and sildenafil on apoptosis and cell proliferation in the lung tissue of SUHx rats.

Abstract

Extracted data

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