Effects of riociguat and sildenafil on sGC and eNOS protein levels, and cGMP concentration in the lung tissue of SUHx rats.
- Michaela Lang (117542)
- Baktybek Kojonazarov (142859)
- Xia Tian (142861)
- Anuar Kalymbetov (142863)
- Norbert Weissmann (5495)
- Friedrich Grimminger (142867)
- Axel Kretschmer (142870)
- Johannes-Peter Stasch (142873)
- Werner Seeger (5494)
- Hossein Ardeschir Ghofrani (142879)
- Ralph Theo Schermuly (142882)
Publication date
August 2012
DOIAbstract
<p>(A) Western blotting of eNOS, sGCα1 and sGCβ1, (B) densitometric analysis of sGCα1/β-actin, (C) densitometric analysis of sGCβ1/β-actin, (D) densitometric analysis of eNOS/β-actin and (E) concentration of cGMP, in lung tissue of different treatment groups. *<i>p</i><0.05. <i>Note.</i> eNOS, endothelial nitric oxide synthase; PDE-5, phosphodiesterase type 5; sGCα1, soluble guanylate cyclase α1; sGC, soluble guanylate cyclase; sGCβ1, soluble guanylate cyclase β1; cGMP, cyclic guanosine monophosphate.</p