<p>Human fibrin clots were prepared and imaged as described in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0043660#s2" target="_blank">methods</a>. When platelet-poor plasma was incubated with 2.5 mM GSNO, image analysis revealed the presence of abnormal fibrin clusters, characterized by high intensity cores with numerous protruding fibers, panels A and B. An unexpected finding was that 3.75 mM GSNO resulted in the formation of fibrin agglomerates, panel C. Panel D is a histogram of agglomerate long axis diameter. A projected binary image from 30,50,70 microns within the plasma sample, revealed the heterogeneous nature of the agglomerates, panel E. See data supplement <a href="http://www.plosone.org/article/info:do...
Fibrinogen gamma' accounts for 3% to 40% of plasma fibrinogen. Earlier studies indicated that fibrin...
© 2017 The Royal Society of Chemistry. The flexible C-terminal parts of fibrinogen's Aα chains named...
BACKGROUND: We recently demonstrated that platelet aggregation occurred in fibrinogen-deficient mice...
<p>Human fibrin clots were prepared and imaged as described in <a href="http://www.plosone.org/artic...
Altered fibrin clot architecture is increasingly associated with cardiovascular diseases; yet, littl...
<p>Images of human fibrin clots in their native state were acquired using multiphoton microscopy and...
<p>Images of native human fibrin clots were acquired using multiphoton microscopy and analyzed using...
<p>Panel A shows a schematic of fiber formation. Fibrinogen is a bisymmetrical molecule consisting o...
<p><a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0055466#pone.0055466-Abbott...
<p>Recalcified whole blood was perfused over glass slides coated with 2.3/cm<sup>2</sup> and type 1 ...
clot levels. resolve the structural underpinnings on scales <1 nm (Hyeon et al., 2006a; Zhmurov e...
Fibrin gel formation is the final result of interaction between multiple plasma proteins; as a resul...
Evidence has emerged to suggest that thrombi are dynamic structures with distinct areas of differing...
<p>(A) Exposure of PS by R-6G labeled platelets (red) in the presence of either (i) FK633 (30 µM), (...
Microscopy imaging has enabled us to establish the presence of fibrin(ogen) amyloid (fibrinaloid) mi...
Fibrinogen gamma' accounts for 3% to 40% of plasma fibrinogen. Earlier studies indicated that fibrin...
© 2017 The Royal Society of Chemistry. The flexible C-terminal parts of fibrinogen's Aα chains named...
BACKGROUND: We recently demonstrated that platelet aggregation occurred in fibrinogen-deficient mice...
<p>Human fibrin clots were prepared and imaged as described in <a href="http://www.plosone.org/artic...
Altered fibrin clot architecture is increasingly associated with cardiovascular diseases; yet, littl...
<p>Images of human fibrin clots in their native state were acquired using multiphoton microscopy and...
<p>Images of native human fibrin clots were acquired using multiphoton microscopy and analyzed using...
<p>Panel A shows a schematic of fiber formation. Fibrinogen is a bisymmetrical molecule consisting o...
<p><a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0055466#pone.0055466-Abbott...
<p>Recalcified whole blood was perfused over glass slides coated with 2.3/cm<sup>2</sup> and type 1 ...
clot levels. resolve the structural underpinnings on scales <1 nm (Hyeon et al., 2006a; Zhmurov e...
Fibrin gel formation is the final result of interaction between multiple plasma proteins; as a resul...
Evidence has emerged to suggest that thrombi are dynamic structures with distinct areas of differing...
<p>(A) Exposure of PS by R-6G labeled platelets (red) in the presence of either (i) FK633 (30 µM), (...
Microscopy imaging has enabled us to establish the presence of fibrin(ogen) amyloid (fibrinaloid) mi...
Fibrinogen gamma' accounts for 3% to 40% of plasma fibrinogen. Earlier studies indicated that fibrin...
© 2017 The Royal Society of Chemistry. The flexible C-terminal parts of fibrinogen's Aα chains named...
BACKGROUND: We recently demonstrated that platelet aggregation occurred in fibrinogen-deficient mice...