Presence of Foxp3⁺ Tregs inside granulomas in the liver of <i>L. donovani</i>-infected <i>aly/aly</i> mice.

<p>Localization of Foxp3-expressing cells in liver sections from <i>aly/+</i> mice and <i>aly/aly</i> mice during the course of <i>L. donovani</i> infection was analyzed by immunohistochemistry using anti-Foxp3 mAb. Typical reactions in the liver parenchyma including “Immature granuloma” and “Mature granulomas” (A) and perivascular areas (B) in uninfected naïve mice and infected mice at 4 and 12 WPI are shown. The brown pigments represent Foxp3-immunoreactive cells.