Significant gene networks associated with neuronal miRNA loss in post-mitotic neurons.

<p>(<b>A</b>) Shown here are IPA-generated pathways. Both upregulated and downregulated genes were included in the analysis. Significant biological functions are associated with the regulation of the cytoskeleton. Relationships are primarily due to co-expression, but can also include phosphorylation/dephosphorylation, proteolysis, activation/deactivation, transcription, binding, inhibition, and biochemical modification. Please refer to <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0044060#pone.0044060.s001" target="_blank">Figure S1</a> for further details. Nefl downregulation (in blue) was confirmed at the protein level in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0044060#pone-0044060-g003" target="_blank">Figure 3</a>. P values were calculated by IPA.