Increased apoptosis in HRC-KD heart under TAC-HF.
- Chang Sik Park (142203)
- Hyeseon Cha (142206)
- Eun Jeong Kwon (142209)
- Dongtak Jeong (142212)
- Roger J. Hajjar (142214)
- Evangelia G. Kranias (35307)
- Chunghee Cho (23258)
- Woo Jin Park (142218)
- Do Han Kim (23257)
Publication date
August 2012
DOIAbstract
<p>TUNEL assay was performed using paraffin-embedded heart sections. A: Results of TUNEL assay. Left, white arrow heads show TUNEL positive pink signal. Right, relative numbers of TUNEL positive cardiomyocyte nuclei (shNC sham: 1±0.46; shNC failure: 4.38±0.21; shHRC sham: 1.6±0.4; shHRC failure: 5.44±0.17). B: Upper, western blot results of caspase 3, cleaved caspase 3, Bax and Bcl-2 from shNC sham, shNC failure, shHRC sham, and shHRC failure mouse hearts. Lower, summary of Bax per Bcl-2 ratio and the expressional changes of the apoptosis marker, cleaved caspase 3 (*<i>P</i><0.05, **<i>P</i><0.01).</p
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