A constant weight reduction and a late-onset deficit in a cerebellar test paradigm.

<p>(A) Homozygous CAG42 mice had a reduced body weight by birth up to the age of 21 months, while no change was observed in heterozygous CAG1/CAG42 mice in comparison to wild-type littermates (n≥14 per genotype). (B) Motor coordination was tested on an accelerating rotarod apparatus. An initially increased locomotor performance at 6 weeks of age in the CAG42 mice was replaced by normal activity at 3, 6 and 12 months. At 18 and 21 months age, CAG42 mice showed impaired motor coordination (until 18 months: n≥14 per genotype, 21 months: n≥6 per genotype).