Cancer-associated interactions between 23 ARSs and AIMPs, and three genesets.

<p>3501 genes were selected by manual curation, clinical examination and causal relationship to cancer. Using 11 public database showing the curated interactions of human proteins (HPRD, BioGRID, KEGG, Reactome, BIND, MINT, IntAct, InnateDB, DIP, STRING, and PharmDB), we further selected 124 DTGs and 404 genes as PPIs of ARSs. Using a cancer-associated interactions analysis, a cancer-association map was established to display how much ARSs and AIMPs could be differently interacted to ten different cancers. Each brown node indicates each gene of respective cancer and each node size indicates the degree of cancer-dependent co-association of a gene. Line indicates the co-association between ten cancers and seven ARSN. The cancer node size indicates the number of interactions with the brown node gene. Seven components of ARSN (green nodes) show relatively higher cancer-associated network.