Bioinformatics analysis of RNA aptamers to identify related sequence and structure families.

<p>(<b>A</b>) RNA aptamer unique sequences (black) are connected to nodes of increasing edit distance (1–9; blue to red color scale). Related sequence families were identified as RNA aptamer sequences that connected by an edit distance of 1 (I–XIII). (<b>B</b>) RNA aptamer sequences (black) were connected to nodes of increasing tree distance (0–18; blue to red color scale). Related structure families were identified as RNA aptamer sequences with structures connected by a tree distance of 3 to 6 (A–H). (<b>C</b>) Venn Diagram of RNA sequences identified based on the edit distance (27 sequences) and tree distance (31 sequences) analyses. Orphan: a highly represented sequence that did not fall into a sequence or structure family.