4b treatment does not affect histone acetylation in mouse brain.
- Maria Beconi (139203)
- Omar Aziz (139206)
- Kim Matthews (139211)
- Lara Moumné (139215)
- Catherine O’Connell (139220)
- Dawn Yates (139224)
- Steven Clifton (139228)
- Hannah Pett (139231)
- Julie Vann (139232)
- Lynsey Crowley (139233)
- Alan F. Haughan (139235)
- Donna L. Smith (139238)
- Ben Woodman (139241)
- Gillian P. Bates (135712)
- Fred Brookfield (139244)
- Roland W. Bürli (139248)
- George McAllister (139252)
- Celia Dominguez (139255)
- Ignacio Munoz-Sanjuan (112471)
- Vahri Beaumont (112469)
Publication date
September 2012
DOIAbstract
<p>(A) Representative immunoblot showing histone acetylation in mouse brain in response to <b>4b</b> treatment. Mice treated with SAHA were used as a positive control (B). Acetylation at specific lysine residues on histone 3 (H3K4, H3K9, H3K14) and Histone 4 (H4K5) as well as global acetylation of H3 (Ac-H3) and H4 (Ac-H4) were studied using specific antibodies. Acetylation level was normalized to H3 and H4 expression level. (C) and (D) Quantification of (A) and (B) respectively. **P<0.01, *P<0.05 versus vehicle (veh). n = four per treatment. Error bars indicate SEM.</p
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