<p>Relative binding free energies of interactions described in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0044471#pone-0044471-g005" target="_blank">Figure 5C</a> were summed across all domains contained in a particular functional category <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0044471#pone.0044471-Liu2" target="_blank">[55]</a> in (<b>A</b>) (see <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0044471#pone.0044471.s032" target="_blank">Table S16</a>) and divided by the number of SH2 domains represented in each class in (<b>B</b>) to determine an average recruitment potential for SH2s from each functional class. (<b>C</b>) ErbB receptor enrichment and depletion ...
<p>Since the free energy is a state function, the calculation of binding affinity is decomposed into...
Multicellular organisms rely on intracellular communication to govern a wide variety of cellular pro...
<p>(a, b) Mapping of the different ERBB3 functions to specific regions of the protein. Each function...
<p>(<b>A</b>) SH2 recruitment potential of ErbB1 family members at different affinity thresholds. Th...
<p>Color-coded heat maps represent apparent dissociation constants (K<sub>D</sub>s) for FP interacti...
<p>(<b>A</b>) Venn diagram comparison of overall SH2 recruitment profiles revealed by FP and PMs for...
AbstractErbB receptor activation is a complex process and is dependent upon the type and number of r...
First-generation interaction maps of Src homology 2 (SH2) domains with receptor tyrosine kinase (RTK...
The mechanisms of context-specific differences in signal transduction, such as those that occur amon...
[[abstract]]First-generation interaction maps of Src homology 2 (SH2) domains with receptor tyrosine...
First-generation interaction maps of Src homology 2 (SH2) domains with receptor tyrosine kinase (RTK...
ErbBjHER proteins belong to receptor tyrosine kinase family and are involved in a complex interactio...
The erythroblastoma (ErbB) receptor family consists of four members that are implicated in many huma...
ErbB2 is a member of the ErbB family of receptor tyrosine kinases, which also includes the epidermal...
Full list of author information is available at the end of the articleBackground The ErbB family of ...
<p>Since the free energy is a state function, the calculation of binding affinity is decomposed into...
Multicellular organisms rely on intracellular communication to govern a wide variety of cellular pro...
<p>(a, b) Mapping of the different ERBB3 functions to specific regions of the protein. Each function...
<p>(<b>A</b>) SH2 recruitment potential of ErbB1 family members at different affinity thresholds. Th...
<p>Color-coded heat maps represent apparent dissociation constants (K<sub>D</sub>s) for FP interacti...
<p>(<b>A</b>) Venn diagram comparison of overall SH2 recruitment profiles revealed by FP and PMs for...
AbstractErbB receptor activation is a complex process and is dependent upon the type and number of r...
First-generation interaction maps of Src homology 2 (SH2) domains with receptor tyrosine kinase (RTK...
The mechanisms of context-specific differences in signal transduction, such as those that occur amon...
[[abstract]]First-generation interaction maps of Src homology 2 (SH2) domains with receptor tyrosine...
First-generation interaction maps of Src homology 2 (SH2) domains with receptor tyrosine kinase (RTK...
ErbBjHER proteins belong to receptor tyrosine kinase family and are involved in a complex interactio...
The erythroblastoma (ErbB) receptor family consists of four members that are implicated in many huma...
ErbB2 is a member of the ErbB family of receptor tyrosine kinases, which also includes the epidermal...
Full list of author information is available at the end of the articleBackground The ErbB family of ...
<p>Since the free energy is a state function, the calculation of binding affinity is decomposed into...
Multicellular organisms rely on intracellular communication to govern a wide variety of cellular pro...
<p>(a, b) Mapping of the different ERBB3 functions to specific regions of the protein. Each function...