<p>(A–C) Lateral views of live 5 dpf larvae injected with Sma or control morpholino. (A) Sma knockdown has no effect on WT intestinal morphology. (B) Control morpholino injection in <i>mlt</i>. (C) Sma knockdown rescues invasion in <i>mlt</i>. Residual invasive cells persist in this Sma deficient <i>mlt</i> larva (arrowhead). (D–I) Histological cross-sections through the posterior intestine of 74 hpf WT and <i>mlt</i> larvae immunostained with anti-keratin (red) and anti-laminin (green) antibodies. (D) WT. (E, F) <i>mlt</i> larvae injected with control (E) and Sma (D, F) morpholinos. Invasive cells in <i>mlt</i> (arrowheads, E) are rescued by Sma knockdown. (G, H) Injection of a morpholino targeting the high molecular weight isoform of Cald...
<p>Endocytosis of tracers WGA (A,B,E,F) and Dextran (C,D,G,H) in wild type (A,E, C,G) and <i>myoVb</...
Smooth muscle is an essential component of the intestine, both to maintain its structure and produce...
The gut epithelium serves to maximize the surface for nutrient and fluid uptake, but at the same tim...
<p>(A–C) Lateral views of live 5 dpf WT (A) and <i>mlt</i> (B, C) larvae. Treatment with the Src-I1 ...
<p>Sagittal confocal images from time lapse movies (Movies S7 and S8) of transgenic WT (A–C) and <i>...
<p>(A) In <i>mlt</i> heterozygotes the expression of mutant Myh11 protein does not generate sufficie...
<p>(A–C) Live images of wild type (WT) and <i>mlt</i> larvae. In WT (A) the posterior intestine form...
<p><b>intestine.</b> (A, B) Full thickness 3-D rendering of sagittal confocal sections through the i...
Coordinated smooth muscle contraction is critical for force production and proper functioning of num...
Coordinated smooth muscle contraction is critical for force production and proper functioning of num...
Coordinated smooth muscle contraction is critical for force production and proper functioning of num...
SummaryZebrafish meltdown (mlt) mutants develop cystic expansion of the posterior intestine as a res...
<p>(A–C) Lateral images of live WT (A), <i>mlt</i> homozygous (B), and <i>mlt</i> heterozygous larva...
International audienceThe intestine is the most anisotropically-shaped organ, but, when grown in cul...
The signals that initiate cell invasion are not well understood, but there is increasing evidence th...
<p>Endocytosis of tracers WGA (A,B,E,F) and Dextran (C,D,G,H) in wild type (A,E, C,G) and <i>myoVb</...
Smooth muscle is an essential component of the intestine, both to maintain its structure and produce...
The gut epithelium serves to maximize the surface for nutrient and fluid uptake, but at the same tim...
<p>(A–C) Lateral views of live 5 dpf WT (A) and <i>mlt</i> (B, C) larvae. Treatment with the Src-I1 ...
<p>Sagittal confocal images from time lapse movies (Movies S7 and S8) of transgenic WT (A–C) and <i>...
<p>(A) In <i>mlt</i> heterozygotes the expression of mutant Myh11 protein does not generate sufficie...
<p>(A–C) Live images of wild type (WT) and <i>mlt</i> larvae. In WT (A) the posterior intestine form...
<p><b>intestine.</b> (A, B) Full thickness 3-D rendering of sagittal confocal sections through the i...
Coordinated smooth muscle contraction is critical for force production and proper functioning of num...
Coordinated smooth muscle contraction is critical for force production and proper functioning of num...
Coordinated smooth muscle contraction is critical for force production and proper functioning of num...
SummaryZebrafish meltdown (mlt) mutants develop cystic expansion of the posterior intestine as a res...
<p>(A–C) Lateral images of live WT (A), <i>mlt</i> homozygous (B), and <i>mlt</i> heterozygous larva...
International audienceThe intestine is the most anisotropically-shaped organ, but, when grown in cul...
The signals that initiate cell invasion are not well understood, but there is increasing evidence th...
<p>Endocytosis of tracers WGA (A,B,E,F) and Dextran (C,D,G,H) in wild type (A,E, C,G) and <i>myoVb</...
Smooth muscle is an essential component of the intestine, both to maintain its structure and produce...
The gut epithelium serves to maximize the surface for nutrient and fluid uptake, but at the same tim...