a<p>Synthetic miRNA were designed to mimic the endogenous miRNA, with ‘+’ indicating the mature miRNA strand, and ‘–’ indicating the passenger strand.</p>b<p>nti-miR inhibitor oligonucleotides were designed complementary to the mature miRNA, with LNA-modified nucleotides preceded by a ‘∧’ symbol.</p
<p>(A) Design of the stem-loop miRNA precursor. The mature sequences of miRNA* species were incorpor...
MicroRNAs (miRNAs) are a class of 20–24 nt noncoding RNAs that regulate target mRNAs post-transcript...
MicroRNAs (miRNAs) are important regulators of gene function and manipulation of miRNAs is a central...
AbstractMany miRNA inhibitors have been developed and they are chemically modified oligonucleotides ...
Abstract Gene regulation is vital for life and it involves plethora of mechanisms including microRNA...
<p>(A) Stem-loop structures of engineered pre-miRNAs. Pre-miRNA-1∼4 were designed to target myostati...
MicroRNAs (miRNAs) are small, non-coding RNA molecules that regulate gene expression posttranscripti...
MicroRNAs (miRNAs) are now recognized as one of the major class of gene regulatory molecules in euka...
Molecules able to interfere in miRNA genesis and function are potent tools to unravel maturation and...
a<p>The selected miRNAs were chemically synthesized in the form of small interfering RNA (siRNA) dup...
Molecules able to interfere in miRNA genesis and function are potent tools to unravel maturation and...
<div><p>The generally accepted model of the miRNA-guided RNA down-regulation suggests that mature mi...
MicroRNAs (miRNAs) are a class of genomically encoded small RNA molecules (∼22nts in length), which ...
<p>The centered sites (nucleotides 5–16 from 5′–end) are indicated by underlined blue letters in bol...
<p>Oligonucleotides used for reporter plasmid construction (Predicted miR target sequences in each g...
<p>(A) Design of the stem-loop miRNA precursor. The mature sequences of miRNA* species were incorpor...
MicroRNAs (miRNAs) are a class of 20–24 nt noncoding RNAs that regulate target mRNAs post-transcript...
MicroRNAs (miRNAs) are important regulators of gene function and manipulation of miRNAs is a central...
AbstractMany miRNA inhibitors have been developed and they are chemically modified oligonucleotides ...
Abstract Gene regulation is vital for life and it involves plethora of mechanisms including microRNA...
<p>(A) Stem-loop structures of engineered pre-miRNAs. Pre-miRNA-1∼4 were designed to target myostati...
MicroRNAs (miRNAs) are small, non-coding RNA molecules that regulate gene expression posttranscripti...
MicroRNAs (miRNAs) are now recognized as one of the major class of gene regulatory molecules in euka...
Molecules able to interfere in miRNA genesis and function are potent tools to unravel maturation and...
a<p>The selected miRNAs were chemically synthesized in the form of small interfering RNA (siRNA) dup...
Molecules able to interfere in miRNA genesis and function are potent tools to unravel maturation and...
<div><p>The generally accepted model of the miRNA-guided RNA down-regulation suggests that mature mi...
MicroRNAs (miRNAs) are a class of genomically encoded small RNA molecules (∼22nts in length), which ...
<p>The centered sites (nucleotides 5–16 from 5′–end) are indicated by underlined blue letters in bol...
<p>Oligonucleotides used for reporter plasmid construction (Predicted miR target sequences in each g...
<p>(A) Design of the stem-loop miRNA precursor. The mature sequences of miRNA* species were incorpor...
MicroRNAs (miRNAs) are a class of 20–24 nt noncoding RNAs that regulate target mRNAs post-transcript...
MicroRNAs (miRNAs) are important regulators of gene function and manipulation of miRNAs is a central...