Distance between like and unlike-charge pairs as a function of the statistical coupling parameter, .

<p>The statistical coupling parameter is a fitting parameter that describes the statistical interaction energy between pairs of states. Since the Bethe mean field pair correlation model is a good approximation for this data, a negative indicates that a pair of states is enhanced (positively correlated), while a positive indicates that a pair of states is suppressed (negatively correlated). Using simple electrostatics, we observe that like-charge patterns (blue) are mostly suppressed while unlike-charge patterns (red) are enhanced. The sign of is able to correctly predict the charge patterns for of the top 35 most significantly correlated charge pairs out of a total of 135 pairs. The p-value for the statistical significance of this result is . The reason there are 135 pairs is as follows: For each pair of residues, there are 4 possible sets of like and unlike charge combinations, resulting in a total of 612 like/unlike charge pair combinations. However, not all pairs exist in the database or are significantly correlated. Filtering results in 135 pairs with probability greater than 0.001%.