Synthesis of Homo- and Heterofunctionalized Glycoclusters and Binding to <i>Pseudomonas aeruginosa</i> Lectins PA-IL and PA-IIL

Homo- and heterofunctionalized glycoclusters with galactose and/or fucose residues targeting both PA-IL and PA-IIL lectins of <i>Pseudomonas aeruginosa</i> were synthesized using “Click” chemistry and DNA chemistry. Their binding to lectins (separately or in a mixture) was studied using a DNA Directed Immobilization carbohydrate microarray. Homoglycoclusters bind selectively to their lectin while the heteroglycocluster binds simultaneously both lectins with a slight lower affinity