Palladium-Assisted Regioselective C–H Cyanation of Heteroarenes Using Isonitrile as Cyanide Source

A palladium-catalyzed regioselective C–H cyanation of heteroarenes was achieved using <i>tert</i>-butyl isocyanide as “CN” source, which provides a new and unique strategy for the preparation of (hetero)aryl nitriles. Indoles, pyrroles, and aromatic rings could be efficiently cyanated through C–H bond activation with high regioselectivity