Characteristic magnitudes and time domains of mechanical signals applied in studies of multipotent cell differentiation.

<p>Each data point represents one study. The shape of the data point portrays the lineage to which the multipotent cell committed. Blue data points depict deviatoric (shape changing) stresses, i.e. shear stress magnitudes [dyn/cm²], and duration of signal over the time course of the study [days]. Red data points depict dilatational stresses (volume changing stresses, <i>i.e.</i> hydrostatic compression and tension, [log₁₀Pa]). The yellow plane (opaque to transparent reflecting respective likelihood of the stress ranges) overlay represents dilatational and deviatoric stress ranges predicted during cell fate determination in utero <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0043601#pone.0043601-Anderson1" target="_blank">[5]</a>, <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0043601#pone.0043601-Wang1" target="_blank">[13]</a>, <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0043601#pone.0043601-Ahsan1" target="_blank">[15]</a>–<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0043601#pone.0043601-Zhang1" target="_blank">[43]</a>.