Adjuvanticity of IMX108 in FcRγ^−/− mice.

<p>Wildtype or FcRγ^−/− mice were immunized i.m. with 1.5×10⁹ ifu Ad42-IMX108 or Ad42-Nil. Two weeks later PyMSP1₃₃-specific IFN-γ, TNFα and IL-2 positive CD8⁺ T cells in the spleen were measured by ICS (A). Box and whisker plots show median, IQR and range for n = 7–13 mice/group. PyMSP1₁₉-specific total IgG was measured by ELISA (B). Points indicate individual mice and bars indicate median titer. n = 6 mice/group. *<i>P</i><0.05, **<i>P</i><0.01, by Mann Whitney test. Combined data are shown from two independent experiments.