(A) Path length distribution.

<p>Frequency distribution of path lengths for all interactions in the network. (B) <b>Bottlenecks.</b> Cartoon representation of the top 10 bottleneck proteins. Solid lines signify 1^st (immediate) neighbor interactions and dotted lines represent 2^nd and 3^rd (nearest) neighbor interactions respectively, as labeled in the figure. (C) <b>Network motifs.</b> Representative clusters (1, 2, 3, 4, 5, and 10) with biological themes that were identified in the network. The highest scoring (seed) nodes in the cluster are shown as squares.