Down-regulation of APM genes during the progression of cervical lesions.

<p>Expression levels of the APM components (TAP-1, TAP-2, LMP2, LMP7, Tapasin, ERAP1, CNX, CRT and ERp57) were analyzed by Semi-quantitative RT-PCR in normal uterine cervix tissue, CIN and CSCC. Compared to the control, CIN and CSCC, mRNA levels were normalized to β-actin mRNA. The upper histogram has shown the expression levels of the APM components in in normal uterine cervix tissue, CIN and CSCC. The results of RT-PCR are represented as means ± SD from 15 controls, 30 CIN and 33 CSCC respectively. * <i>P</i> < 0.05.