<p>(A–B) Autopsy preparations of abdominal viscera in newborns. Superficial (left panel), profound (medium panel) and corresponding scheme (right panel) are shown. Mutant embryos exhibit relatively normal stomach and midgut but hypoplastic kidneys and hindgut and absence of bladder. (C–D) H&E-stained mid sagittal sections of wild-type (C) and <i>Bmp7<sup>−/−</sup>;Shh<sup>+/−</sup></i> mutants (D) at the embryonic stage indicated at the top. The yellow arrows indicate the hindgut and the blue arrows the urethra. Note the absence of urogenital duct and septum in mutants. Abbreviations: b: bladder; g: gonad and gonadal duct; hg: hindgut; k: kidney; u: urachus. The urogenital septum is indicated by an asterisk.</p
<p>All frames are from E14 organs. <b>A</b>, <b>C</b> and <b>E</b> are from wild type mice (-/-) and...
<p>38 somite stage E10.5 embryos were stained with the epithelial markers Pax2 (red) and E-cadherin ...
<p>All panels are frontal sections of E10.5 embryos. <b>A</b>,<b>B</b>, control and littermate <i>Tb...
<p>Semithin (1 micron thick) transverse serial sections stained with toluidine blue of control and m...
<p>(<b>A</b>) A table of urogenital phenotypes of <i>Six1;Six2</i> compound mutants. (<b>B</b>–<b>G<...
<p>A) Heterozygous (<i>Sd</i>/+) mouse. B) Wildtype (+/+) mouse. C) Homozygous (<i>Sd/Sd</i>) P0 neo...
<p>Urogenital systems were dissected at E18.5 and either processed as whole mount (A–G) or subjected...
<p>(A–H) Embryos were labelled with anti-DECad, and serial z-stacked images spanning the upper half ...
<p>(A) Differentiated intestinal cells stained with ICB4 antibody. The first two panels of the top r...
<p>A. Confocal images of the visceral endoderm (arrowhead, outermost cell layer) and adjacent mesode...
<p>Gross morphology of the urinary tracts in the control (<b>A</b>) and <i>Shh<sup>−/−</sup></i> (<b...
<p>H & E stained E18.5 sections of wild-type (WT) (left) and <i>Nmnat2<sup>blad/blad</sup></i> (BLAD...
<p><b>A.</b> Representative images of Hematoxylin & Eosin (H&E) staining on control and <i>Pik3c3</i...
<p>Hh-responsive cell contribution assay was performed by utilizing the <i>Gli1<sup>CreERT2</sup>; R...
<div><p>Anterior is left in all figures.</p> <p>(A–F) Embryos are stained with anti-Vasa...
<p>All frames are from E14 organs. <b>A</b>, <b>C</b> and <b>E</b> are from wild type mice (-/-) and...
<p>38 somite stage E10.5 embryos were stained with the epithelial markers Pax2 (red) and E-cadherin ...
<p>All panels are frontal sections of E10.5 embryos. <b>A</b>,<b>B</b>, control and littermate <i>Tb...
<p>Semithin (1 micron thick) transverse serial sections stained with toluidine blue of control and m...
<p>(<b>A</b>) A table of urogenital phenotypes of <i>Six1;Six2</i> compound mutants. (<b>B</b>–<b>G<...
<p>A) Heterozygous (<i>Sd</i>/+) mouse. B) Wildtype (+/+) mouse. C) Homozygous (<i>Sd/Sd</i>) P0 neo...
<p>Urogenital systems were dissected at E18.5 and either processed as whole mount (A–G) or subjected...
<p>(A–H) Embryos were labelled with anti-DECad, and serial z-stacked images spanning the upper half ...
<p>(A) Differentiated intestinal cells stained with ICB4 antibody. The first two panels of the top r...
<p>A. Confocal images of the visceral endoderm (arrowhead, outermost cell layer) and adjacent mesode...
<p>Gross morphology of the urinary tracts in the control (<b>A</b>) and <i>Shh<sup>−/−</sup></i> (<b...
<p>H & E stained E18.5 sections of wild-type (WT) (left) and <i>Nmnat2<sup>blad/blad</sup></i> (BLAD...
<p><b>A.</b> Representative images of Hematoxylin & Eosin (H&E) staining on control and <i>Pik3c3</i...
<p>Hh-responsive cell contribution assay was performed by utilizing the <i>Gli1<sup>CreERT2</sup>; R...
<div><p>Anterior is left in all figures.</p> <p>(A–F) Embryos are stained with anti-Vasa...
<p>All frames are from E14 organs. <b>A</b>, <b>C</b> and <b>E</b> are from wild type mice (-/-) and...
<p>38 somite stage E10.5 embryos were stained with the epithelial markers Pax2 (red) and E-cadherin ...
<p>All panels are frontal sections of E10.5 embryos. <b>A</b>,<b>B</b>, control and littermate <i>Tb...