Fodrin cleavage and effect of calpain inhibition in clofibrate-treated cells.

<p>(A) Representative western blotting of fodrin cleavage in clofibrate (CF)-exposed Jurkat cells in the presence or in the absence of zVAD and calpeptin. (B) Cells were pretreated with the calpain inhibitors calpeptin or PD150606, then exposed to CF and analysed after 45min. Histograms refer to percentages of cells with hypodiploid DNA content (black bars: untreated; grey bars: CF-treated). Data are expressed as mean ± SD (n = 3). ** p<0,01 vs Co; *** p<0,001 vs Co; §§§ p<0,001 vs CF.