Comparison of inter-burst intervals in simulations and experiments.

<p>Typical examples of experimental (A) and simulated (B) IBI histograms constructed from 1 h samples with 355 and 373 bursts respectively, both acquired at 18 DIV. The simulated IBI histogram was generated with a field-guided network of 10,000 neurons with large GABA-ergic neurons. The three other model types had very similar IBI distributions. Bin size was calculated according to <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0043352#pone.0043352-Meier1" target="_blank">[43]</a>. (C): Development of IBI median for experiments, acquired from 5 cortical cultures (thin solid lines) and simulated data (thick dashed lines). Randomly growing networks with (magenta ○) and without large GABA-ergic neurons (red ◊) as well as field-guided networks with (green □) and without large GABA-ergic neurons (blue •) are shown.