Stathmin is not required for tumor onset following DMBA/TPA treatment in mice.

<p>(A) Kaplan Meier curves of tumor-free WT, stathmin heterozygous and KO mice challenged with the 7,12-dimethylbenz[α]antracene (DMBA)/12-O-tetradecanoylphorbol-13-acetate (TPA) protocol, using as endpoint 20 weeks of treatment. p = n.s., using the Log Rank test. (B) Evaluation of the number of tumors/mice in function of time. <i>p = n.s.,</i> using the Mann Whitney test. (C) Macroscopic and microscopic analyses of papillomas in mice of the indicated genotypes. Typical images are reported. H&E = hematoxylin and eosin staining. CK1 = IHC analysis of cytokeratin 1 expression. Loricrin = IHC analysis of loricrin expression.