Architecture of response regulators present in <i>cheR-TPR</i> containing gene clusters.

<p>The segment shown in dark blue corresponds to single-domain response regulators that are composed of a single receiver domain (REC). The remaining response regulators are multidomain proteins and listed are the domain(s) which are fused to the REC domain. <b>HISKA</b>: histidine kinase A (dimerization/phosphoacceptor) domain, cl00080; <b>HATPase</b>: histidine kinase-like ATPases, cd00075: <b>HPT</b>: histidine phosphotransfer domain, cd 00088; <b>REC</b>: response regulator receiver domain, cd 00156; <b>PAS</b>: superfamily of per-arn-sim domains, cl02459; <b>GGDEF</b>: diguanylate-cyclase, cd01949; <b>EAL</b>: diguanylate phosphodiesterase, cd 01948; <b>Ser/Thr phosphatase</b>: family 2C, cl00120; <b>metal-dependent phosphatase</b>: cd 00077; <b>transcriptional regulator</b>: cd00383; <b>AAA+ ATPase</b>: cd 00009; <b>mononucleotidyl cyclase</b>: cd 07302, contain adenylate cyclases and guanylate cyclases. Detailed information of this analysis is found in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0045810#pone.0045810.s007" target="_blank">Table S2</a>.