Sex-dependent synaptic hyperactivity in the prefrontal cortex is observed at different ages in 3xTg-AD mice.

<p>(<b>A</b>) Examples of miniature inhibitory post synaptic currents (mIPSCs) recorded from pyramidal cells of NonTg and 3xTg-AD mice at different ages. Scale bar 50 pA/1 s (<b>B</b>) A significant increase in mIPSC frequency was observed at 12 months in 3xTg-AD females, but was delayed until 18 months in males, <i>n</i> = 6 to 8 cells per group *<i>p</i><0.05 Student t-test. (<b>C</b>) and (<b>D</b>) A significant increase in miniature excitatory post synaptic currents (mEPSC) activity was observed at 12 months in 3xTg-AD females and at 18 month in 3xTg-AD males, <i>n</i> = 5 to 7 cells per group; *<i>p</i><0.05. Scale bar 25 pA/1 s. (<b>E and F</b>) No changes in mPSC amplitude were observed among the groups compared, <i>n</i> = 5 to 8 cells per group.