Effects of <i>PER3</i> genotypes on the circadian modulation of performance during total sleep deprivation following partial sleep deprivation.

<p><i>(</i><b><i>A</i></b><i>)</i> Verbal 3-back performance during total sleep deprivation (TSD) in the Sleep Restriction (filled symbols) and the Control conditions (open circles) separately for the three <i>PER3</i> genotypes. (DLMO: dashed grey vertical line and melatonin profile averaged between the two conditions shaded in grey). <i>(</i><b><i>B</i></b><i>)</i> Effect sizes for the Genotype × Sleep History Condition interaction during TSD for Subjective Alertness, Sustained Attention, and Working Memory, computed for each 4-h circadian melatonin bin. <i>(</i><b><i>C</i></b><i>)</i> Effect size averaged across the six performance measures. Error bars represent the between performance measure standard error of the mean. Horizontal lines indicate cut-offs for small and medium effect sizes.