Inactivation properties of Kv11.1-1A and Kv11.1-3.1.

<p>A. Typical family of Kv11.1-1A (left) and Kv11.1-3.1 (right) current traces recorded at 37°C during a protocol to measure rates of inactivation (voltage protocol shown at top of panel A, dashed box highlights the part of the traces shown). B. Magnification of the first 8 ms of the +60 mV step for Kv11.1-1A (grey) and Kv11.1-3.1 (black) indicating slower inactivation for Kv11.1-3.1 compared to Kv11.1-1A. C. Summary of rates of recovery from inactivation for Kv11.1-1A (□) and Kv11.1-3.1 (▪) (τ_recov, measured from protocol shown in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0045624#pone-0045624-g003" target="_blank">Fig. 3</a>) over the voltage range −130 mV to −40 mV and rates of inactivation (τ_inact) for Kv11.1-1A (○) and Kv11.1-3.1 (•) over the voltage range <b>−</b>30 mV to +60 mV. Solid lines are the best fits of <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0045624#pone.0045624.e002" target="_blank">equation 2</a> to the data (see <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0045624#s2" target="_blank">materials and methods</a>). D. Midpoint of stead-state inactivation for Kv11.1-1A (○) and Kv11.1-3.1 (•) measured as the voltage at which τ_inact = τ_recov (see methods for details). ***: p<0.001.