Cartoon of the different folded/unfolded states.

<p>The cartoon represents reduced and oxidized leptin, seen in the <i>top-</i> and <i>bottom panel</i> respectively. The <i>left-</i> and <i>right panel</i> shows the denatured and native state respectively. The grey colour indicates the interconversion between two constructs as a result of the numerical simulation where the disulphide bond is continuously made and broken during simulation (). Spontaneous reduction of the protein (grey pathway) is not observed experimentally.