RNA interference (RNAi)using antisense DNA or RNA oligonucleotides to silence activity of a specific pathogenic gene transcript and reduce expression of the encoded proteinis very useful in dissecting genetic function and holds significant promise as a molecular therapeutic. A major obstacle in achieving gene silencing with RNAi technology is the systemic delivery of therapeutic oligonucleotides. Here we demonstrate an engineered gold nanoshell (NS)-based therapeutic oligonucleotide delivery vehicle, designed to release its cargo on demand upon illumination with a near-infrared (NIR) laser. A <b>poly-l-lysine</b> peptide (PLL) epilayer covalently attached to the NS surface (NS-PLL) is used to capture intact, single-stranded antisense DNA ...
Transient, non-integrative modulation of cell function by intracellular delivery of proteins has hig...
Day, Emily S.Nanoparticles (NPs) are promising tools to improve upon conventional cancer treatment s...
This study provides a unique approach to activate caged small interfering RNAs (siRNAs) using indire...
RNA interference (RNAi), a process that can silence specific genes, has been recognized for its pote...
Abstract The potential of microRNA regulation in oncotherapy is limited by the lack of delivery vehi...
Novel RNA-based technologies provide an avenue of possibilities to control the regulation of gene ex...
We describe a near infrared (NIR) light-activated gene silencing method in undifferentiated human em...
Laser based transfection methods have proven to be an efficient and gentle alternative to establishe...
ABSTRACT: We have combined a versatile and powerful route to deliver nucleic acids with peptide-base...
Intracellular delivery of biomolecules is hindered by both the size and charge of the biomolecule. ...
We present a robust method for loading small interfering RNA (siRNA) duplexes onto the surfaces of g...
Laser based transfection methods have proven to be an efficient and gentle alternative to establishe...
Plasmon-resonant nanoparticle complexes show promising potential for light-triggered, controllable d...
Gene therapy arises as a great promise for cancer therapeutics due to its potential to silence genes...
The selective exposure of cancerous tissue to systemically delivered chemotherapeutic agents remains...
Transient, non-integrative modulation of cell function by intracellular delivery of proteins has hig...
Day, Emily S.Nanoparticles (NPs) are promising tools to improve upon conventional cancer treatment s...
This study provides a unique approach to activate caged small interfering RNAs (siRNAs) using indire...
RNA interference (RNAi), a process that can silence specific genes, has been recognized for its pote...
Abstract The potential of microRNA regulation in oncotherapy is limited by the lack of delivery vehi...
Novel RNA-based technologies provide an avenue of possibilities to control the regulation of gene ex...
We describe a near infrared (NIR) light-activated gene silencing method in undifferentiated human em...
Laser based transfection methods have proven to be an efficient and gentle alternative to establishe...
ABSTRACT: We have combined a versatile and powerful route to deliver nucleic acids with peptide-base...
Intracellular delivery of biomolecules is hindered by both the size and charge of the biomolecule. ...
We present a robust method for loading small interfering RNA (siRNA) duplexes onto the surfaces of g...
Laser based transfection methods have proven to be an efficient and gentle alternative to establishe...
Plasmon-resonant nanoparticle complexes show promising potential for light-triggered, controllable d...
Gene therapy arises as a great promise for cancer therapeutics due to its potential to silence genes...
The selective exposure of cancerous tissue to systemically delivered chemotherapeutic agents remains...
Transient, non-integrative modulation of cell function by intracellular delivery of proteins has hig...
Day, Emily S.Nanoparticles (NPs) are promising tools to improve upon conventional cancer treatment s...
This study provides a unique approach to activate caged small interfering RNAs (siRNAs) using indire...