Classification of 48 triple-negative breast cancer patients using the 45-gene metastasis predictor set.

<p>(A) Gene expression data of the 45 genes from 48 triple-negative patients in a heat map. Each row represents a gene and each column represents a patient. Triple-negative breast cancer patients who developed distant metastases during the three years of follow-up were indicated with a black bar at the bottom of each column (white: distant-metastasis negative, black: distant-metastasis positive). The yellow line represents the metastasis predictor with optimal accuracy (sensitivity: 89%; specificity: 100%). The poor prognosis group (left) and the good prognosis group (right) were separated by the yellow line. (B) Rank-ordered Pearson correlation coefficients of 48 triple-negative patients with respect to the centroid profile of the metastasis-positive group (n = 9).