Kaplan Meier survival analysis of Met kinetic signature’s segmentation of human breast cancer patient cohorts.

<p>Hierarchical clustering was used to divide six large breast cancer patient cohorts into high vs. low Met kinetic signature. Kaplan Meier analysis of overall survival (A,B,C,D,E) and metastasis-free survival (F,G) of the Chang (A, F, H, I), Miller (B), GSE1456 (C), GSE3165 (D), GSE11121 (E) and van ‘t veer (G) data sets. Kaplan Meier analysis of overall survival (H) and metastasis-free survival (I) of stage-I patients in the Chang data set. A red line denotes patients with high Met kinetic signature and a blue line denotes patients with low Met kinetic signature. In Chang data set, Met kinetic signature has a positive predictive value (PPV) and negative predictive value (NPV) of 41% and 82%, respectively.