TGF-β1 and 2, NOX2 and NOX4 are up-regulated in human samples from patients with HCV-derived fibrosis.

<p>Samples from patients showing control livers (control; n = 10), low or mildly fibrotic livers (F0–F2; n = 16) or severely fibrotic and cirrhotic livers (F3/F4; n = 12). Real time determination of TGF-β₁(<i>TGFB1</i>), TGF-β₂ (<i>TGFB2</i>), TGF-β₃ (<i>TGFB3</i>) (<i>A</i>), TGFβRI and TGFβRII (<i>TGFBR1</i>, <i>TGFBR2</i>) (<i>B</i>), and <i>NOX1</i>, <i>NOX2</i> and <i>NOX4</i> (<i>C</i>). Statistic was calculated using one-way ANOVA associated with Dunnett's test.