iPSCs generated from one dura fibroblast line express pluripotency markers and differentiate to neuronal fates.
- Lindsay A. Bliss (132933)
- Malik R. Sams (132938)
- Amy Deep-Soboslay (67661)
- Renee Ren-Patterson (132945)
- Andrew E. Jaffe (132950)
- Josh G. Chenoweth (132955)
- Amritha Jaishankar (132958)
- Joel E. Kleinman (67665)
- Thomas M. Hyde (67664)
Publication date
September 2012
DOIAbstract
<p>Undifferentiated iPSCs express pluripotency markers NANOG (A) and SOX2 (B). Upon neural differentiation, these cells express neuroectoderm marker SOX1 (C). Temporal gene expression analysis also shows a decrease in pluripotency marker OCT4 (POU5F1) and an increase in <i>PAX6</i> expression by quantitative RT-PCR (D). iPSC-derived neurons express βIII-tubulin and MAP2 (E–G).</p
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